What is Glanzmann's thrombasthenia?

In Glanzmann’s thrombasthenia, platelets do not stick to each other properly due to an abnormality in the structure of the platelet wall (a protein called GP IIb/IIIa is to blame). This is an essential step in forming a blood clot, or primary platelet plug. Abnormal bleeding is the result of this problem.

Bleeding symptoms range from mild to severe and include:

• Bleeding into the mucous membranes (e.g. mouth and nose linings) - this includes bleeding in the mouth and nosebleeds
• Bleeding after surgery or trauma can be severe
• Bleeding tendency is usually discovered in childhood, and may progressively worsen throughout puberty and adult life
• Excessive menstrual bleeding
• Bleeding in the urinary tract (usually the bladder)
• Bleeding in joints (unusual)
• Small blood spots in the skin.

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_{Last updated: 2007-04-27}